(B) Normal internal genital organs are visible, and there is no evidence of female genital organs on the T2-weighted magnetic resonance image. In this study, we present an SRY-negative 46,XX Korean boy who presented with small testes and without any genital ambiguity. Molecular genetic studies confirmed SOX9 duplication as the cause of 46,XX testicular DSD for the first time in Korea.
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Two PET studies reported that males and females process thermal pain differently, though both the methodology and the pattern of results differed substantially between studies. Paulson et al312 found that females reported more pain than males in response to a 50 °C contact heat stimulus, with an accompanying higher level of activation in the contralateral thalamus and anterior insula. Derbyshire et al91 tailored a laser heat stimulus to produce comparable pain levels in men and women and found that males showed greater activation in some brain regions (eg, parietal cortex, SII, PFC, insula), whereas females showed greater activation in others (eg, perigenual cortex, cingulate cortex). Clearly, additional studies are needed to further characterize differences in pain-related brain activity between males and females.
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